Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

Abstract How cells coordinate cell cycling with cell survival and death remains incompletely understood. Here, we show that cell cycle arrest has a potent suppressive effect on ferroptosis, a form of regulated cell death induced by overwhelming lipid peroxidation at cellular membranes. Mechanistical...

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Bibliographic Details
Main Authors: Hyemin Lee, Amber Horbath, Lavanya Kondiparthi, Jitendra Kumar Meena, Guang Lei, Shayani Dasgupta, Xiaoguang Liu, Li Zhuang, Pranavi Koppula, Mi Li, Iqbal Mahmud, Bo Wei, Philip L. Lorenzi, Khandan Keyomarsi, Masha V. Poyurovsky, Kellen Olszewski, Boyi Gan
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44412-7

Internet

https://doi.org/10.1038/s41467-023-44412-7

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