(2<i>R</i>, 4<i>S</i>, 5<i>S</i>) 1-(4-(4-(((7-Chloroquinolin-4-yl)amino)methyl)-1<i>H</i>-1,2,3-triazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dione

(2<i>R</i>, 4<i>S</i>, 5<i>S</i>) 1-(4-(4-(((7-Chloroquinolin-4-yl)amino)methyl)-1<i>H</i>-1,2,3-triazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dione

1,2,3-triazole pharmacophore is a widely recognized motif used for a variety of applications, including drug discovery, chemical biology, and materials science. We herein report the synthesis of a derivative of azidothymidine (AZT), which was combined with the 7-chloro quinoline scaffold through a 1...

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Bibliographic Details
Main Authors: Houin Kuan, Yuhan Xie, Yuzhu Guo, Alessandra Gianoncelli, Giovanni Ribaudo, Paolo Coghi
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Molbank
Subjects:
HIV
1,2,3-triazole
drug discovery
molecular docking
Online Access:https://www.mdpi.com/1422-8599/2023/3/M1681

Internet

https://www.mdpi.com/1422-8599/2023/3/M1681

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