Binding domain on CD22 molecules contributing to the biological activity of T cell-engaging bispecific antibodies

Binding domain on CD22 molecules contributing to the biological activity of T cell-engaging bispecific antibodies

CD22, as the B-cell malignancies antigen, has been targeted for immunotherapies through CAR-T cells, antibody-drug conjugates (ADCs) and immunotoxins via interaction of antibodies with binding domains on the receptor. We hypothesized that avidity and binding domain of antibody to target cells may ha...

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Bibliographic Details
Main Authors: Jie Chen, Zhidi Pan, Lei Han, Junjun Liu, Yali Yue, Xiaodong Xiao, Baohong Zhang, Mingyuan Wu, Yunsheng Yuan, Yanlin Bian, Hua Jiang, Yueqing Xie, Jianwei Zhu
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Heliyon
Subjects:
T cell-engaging bispecific antibody
CD22
Avidity
Binding domain
Online Access:http://www.sciencedirect.com/science/article/pii/S240584402305168X

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http://www.sciencedirect.com/science/article/pii/S240584402305168X

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