Poly(ADP)-Ribosylation Inhibition: A Promising Approach for Clear Cell Renal Cell Carcinoma Therapy

Poly(ADP)-Ribosylation Inhibition: A Promising Approach for Clear Cell Renal Cell Carcinoma Therapy

Poly(ADP-ribose) polymerase 1 (PARP-1) and glycohydrolase (PARG) enzymes regulate chromatin structure, transcription activation, and DNA repair by modulating poly(ADP-ribose) (pADPr) level. Interest in PARP-1 inhibitors has soared recently with the recognition of their antitumor efficacy. We have sh...

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Bibliographic Details
Main Authors: Yaroslava Karpova, Danping Guo, Peter Makhov, Adam M. Haines, Dmitriy A. Markov, Vladimir Kolenko, Alexei V. Tulin
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
PARylation
PARG
PARP-1 inhibitors
poly(ADP-ribose)
RCC
cancer cell
Online Access:https://www.mdpi.com/2072-6694/13/19/4973

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https://www.mdpi.com/2072-6694/13/19/4973

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