Highly Selective Targeting of Pancreatic Cancer in the Liver with a Near-Infrared Anti-MUC5AC Probe in a PDOX Mouse Model: A Proof-of-Concept Study

Highly Selective Targeting of Pancreatic Cancer in the Liver with a Near-Infrared Anti-MUC5AC Probe in a PDOX Mouse Model: A Proof-of-Concept Study

Accurately identifying metastatic disease is critical to directing the appropriate treatment in pancreatic cancer. Mucin 5AC is overexpressed in pancreatic cancer but absent in normal pancreas tissue. The present proof-of-concept study demonstrates the efficacy of an anti-mucin 5AC antibody conjugat...

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Bibliographic Details
Main Authors: Michael A. Turner, Kristin E. Cox, Nicholas Neel, Siamak Amirfakhri, Hiroto Nishino, Bryan M. Clary, Mojgan Hosseini, Gopalakrishnan Natarajan, Kavita Mallya, Aaron M. Mohs, Robert M. Hoffman, Surinder K. Batra, Michael Bouvet
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Journal of Personalized Medicine
Subjects:
pancreatic cancer
liver metastasis
selective targeting
fluorescent antibody
imaging
mucin
Online Access:https://www.mdpi.com/2075-4426/13/5/857

Internet

https://www.mdpi.com/2075-4426/13/5/857

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