Peripheral gene signatures reveal distinct cancer patient immunotypes with therapeutic implications for autologous DC-based vaccines

Peripheral gene signatures reveal distinct cancer patient immunotypes with therapeutic implications for autologous DC-based vaccines

Dendritic cells (DCs) have received considerable attention as potential targets for the development of novel cancer immunotherapies. However, the clinical efficacy of DC-based vaccines remains suboptimal, largely reflecting local and systemic immunosuppression at baseline. An autologous DC-based vac...

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Bibliographic Details
Main Authors: Michal Hensler, Jana Rakova, Lenka Kasikova, Tereza Lanickova, Josef Pasulka, Peter Holicek, Marek Hraska, Tereza Hrnciarova, Pavla Kadlecova, Andreu Schoenenberger, Klara Sochorova, Daniela Rozkova, Ludek Sojka, Jana Drozenova, Jan Laco, Rudolf Horvath, Michal Podrazil, Guo Hongyan, Tomas Brtnicky, Michal J. Halaska, Lukas Rob, Ales Ryska, An Coosemans, Ignace Vergote, Abhishek D. Garg, David Cibula, Jirina Bartunkova, Radek Spisek, Jitka Fucikova
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:OncoImmunology
Subjects:
Cancer immunotherapy
metastatic castrate-resistant prostate cancer
non-small cell lung carcinoma
epithelial ovarian carcinoma
circulating biomarkers
anti-PD-1
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2022.2101596

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https://www.tandfonline.com/doi/10.1080/2162402X.2022.2101596

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