Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate[S]

Functional rescue of mutant ABCA1 proteins by sodium 4-phenylbutyrate[S]

Mutations in the ATP-binding cassette transporter A1 (ABCA1) are a major cause of decreased HDL cholesterol (HDL-C), which infers an increased risk of cardiovascular disease (CVD). Many ABCA1 mutants show impaired localization to the plasma membrane. The aim of this study was to investigate whether...

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Bibliographic Details
Main Authors: Brie Sorrenson, Rachel J. Suetani, Michael J.A. Williams, Vivienne M. Bickley, Peter M. George, Gregory T. Jones, Sally P.A. McCormick
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Journal of Lipid Research
Subjects:
ATP-binding cassette transporter
high density lipoprotein
atherosclerosis
cholesterol efflux
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520417614

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http://www.sciencedirect.com/science/article/pii/S0022227520417614

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