Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration

Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration

Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) transcriptional coactivators are key regulators of energy metabolism-related genes and are expressed in energy-demanding tissues. There are several PGC-1α variants with different biological functions in different tissues. The b...

Full description

Bibliographic Details
Main Authors: M.J. Nunes, A.N. Carvalho, C. Sá-Lemos, M. Colaço, I. Cervenka, V. Ciraci, S.G. Santos, M.M. Ribeiro, M. Castanheira, P.R. Jannig, M.J. Gama, M. Castro-Caldas, C.M.P. Rodrigues, E. Rodrigues, J.L. Ruas
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:European Journal of Cell Biology
Subjects:
Parkinson’s disease
PGC-1α
Isoforms
Variants
PGC-1α2
PGC-1α3
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933523000924

Internet

http://www.sciencedirect.com/science/article/pii/S0171933523000924

Similar Items