Heterozygous Cystic Fibrosis Transmembrane Regulator Gene Missense Variants Are Associated With Worse Cardiac Function in Patients With Duchenne Muscular Dystrophy

Heterozygous Cystic Fibrosis Transmembrane Regulator Gene Missense Variants Are Associated With Worse Cardiac Function in Patients With Duchenne Muscular Dystrophy

Background Duchenne muscular dystrophy (DMD) is a neuromuscular disorder caused by mutations within the dystrophin gene. DMD is characterized by progressive skeletal muscle degeneration and atrophy and progressive cardiomyopathy. It has been observed the severity of cardiomyopathy varies in patients...

Full description

Bibliographic Details
Main Authors: Xuan Jiang, Yanqiu Shao, Faris G. Araj, Alpesh A. Amin, Benjamin M. Greenberg, Mark H. Drazner, Chao Xing, Pradeep P. A. Mammen
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
Duchene muscular dystrophy–associated cardiomyopathy
genetic modifier
whole exome sequencing
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.016799

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.016799

Similar Items