VEGFR2-Mediated Vascular Dilation as a Mechanism of VEGF-Induced Anemia and Bone Marrow Cell Mobilization

VEGFR2-Mediated Vascular Dilation as a Mechanism of VEGF-Induced Anemia and Bone Marrow Cell Mobilization

Molecular mechanisms underlying tumor VEGF-induced host anemia and bone marrow cell (BMC) mobilization remain unknown. Here, we report that tumor VEGF markedly induced sinusoidal vasculature dilation in bone marrow (BM) and BMC mobilization to tumors and peripheral tissues in mouse and human tumor m...

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Bibliographic Details
Main Authors: Sharon Lim, Yin Zhang, Danfang Zhang, Fang Chen, Kayoko Hosaka, Ninghan Feng, Takahiro Seki, Patrik Andersson, Jingrong Li, Jingwu Zang, Baocun Sun, Yihai Cao
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714007712

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http://www.sciencedirect.com/science/article/pii/S2211124714007712

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