Urea amidolyase (DUR1,2) contributes to virulence and kidney pathogenesis of Candida albicans.

Urea amidolyase (DUR1,2) contributes to virulence and kidney pathogenesis of Candida albicans.

The intracellular enzyme urea amidolyase (Dur1,2p) enables C. albicans to utilize urea as a sole nitrogen source. Because deletion of the DUR1,2 gene reduces survival of C. albicans co-cultured with a murine macrophage cell line, we investigated the role of Dur1,2p in pathogenesis using a mouse mode...

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Bibliographic Details
Main Authors: Dhammika H M L P Navarathna, Michail S Lionakis, Martin J Lizak, Jeeva Munasinghe, Kenneth W Nickerson, David D Roberts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3483220?pdf=render

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http://europepmc.org/articles/PMC3483220?pdf=render

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