Preclinical Studies of the Off-Target Reactivity of AFP158-Specific TCR Engineered T Cells
Autologous T cells engineered with T receptor genes (TCR) are being studied to treat cancers. We have recently identified a panel of mouse TCRs specific for the HLA-A0201/alpha fetoprotein epitope (AFP158) complex and have shown that human T cells engineered with these TCR genes (TCR-Ts) can eradica...
Principais autores: | , , , , , , , |
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Formato: | Artigo |
Idioma: | English |
Publicado em: |
Frontiers Media S.A.
2020-04-01
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coleção: | Frontiers in Immunology |
Assuntos: | |
Acesso em linha: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00607/full |