Preclinical Studies of the Off-Target Reactivity of AFP158-Specific TCR Engineered T Cells

Preclinical Studies of the Off-Target Reactivity of AFP158-Specific TCR Engineered T Cells

Autologous T cells engineered with T receptor genes (TCR) are being studied to treat cancers. We have recently identified a panel of mouse TCRs specific for the HLA-A0201/alpha fetoprotein epitope (AFP158) complex and have shown that human T cells engineered with these TCR genes (TCR-Ts) can eradica...

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Bibliographic Details
Main Authors: Lun Cai, Leidy D. Caraballo Galva, Yibing Peng, Xiaobing Luo, Wei Zhu, Yihong Yao, Yun Ji, Yukai He
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
T cell receptors
T cell engineering
alpha fetoprotein
hepatocellular carcinoma
TCR cross-reactivity
off-target toxicity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00607/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00607/full

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