Comparative sensitivity of automated (Abbott M2000) and manual plasma HIV-1 RNA PCR assays for the detection of persistent viremia after long-term antiretroviral therapy

Comparative sensitivity of automated (Abbott M2000) and manual plasma HIV-1 RNA PCR assays for the detection of persistent viremia after long-term antiretroviral therapy

Background: The ability of automated, FDA-cleared plasma HIV-1 RNA assays to detect low-level viremia, compared to manual, highly sensitive research-only methods, is not well-defined. We therefore tested paired plasma samples from people with HIV-1 (PWH) on long-term antiretroviral therapy (ART) wit...

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Bibliographic Details
Main Authors: Melissa A. Tosiano, Hanna Mar, Dianna Hoeth, Joseph J. Eron, Rajesh T. Gandhi, Deborah K. McMahon, Ronald J. Bosch, John W. Mellors, Joshua C. Cyktor
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Virus Eradication
Subjects:
HIV-1
Low-level viremia
Quantification
Automation
Clinical trials
Online Access:http://www.sciencedirect.com/science/article/pii/S2055664022000334

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http://www.sciencedirect.com/science/article/pii/S2055664022000334

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