Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts

Interplay between symmetric arginine dimethylation and ubiquitylation regulates TDP1 proteostasis for the repair of topoisomerase I-DNA adducts

Summary: Tyrosyl-DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond between a DNA 3′ end and a tyrosyl moiety and is implicated in the repair of trapped topoisomerase I (Top1)-DNA covalent complexes (Top1cc). Protein arginine methyltransferase 5 (PRMT5) catalyzes arginine methylation of...

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Bibliographic Details
Main Authors: Sangheeta Bhattacharjee, Ishita Rehman, Saini Basu, Souvik Nandy, Julia M. Richardson, Benu Brata Das
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722007227

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http://www.sciencedirect.com/science/article/pii/S2211124722007227

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