Gallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation

Gallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation

We previously reported that lysine-demethylase 2A (KDM2A), a Jumonji-C histone demethylase, is activated by gallic acid to reduce H3K36me2 levels in the rRNA gene promoter and consequently inhibit rRNA transcription and cell proliferation in the breast cancer cell line MCF-7. Gallic acid activates A...

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Bibliographic Details
Main Authors: Yuji Tanaka, Makoto Tsuneoka
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomolecules
Subjects:
rRNA transcription
breast cancer
KDM2A
gallic acid
propyl gallate
epigallocatechin gallate
Online Access:https://www.mdpi.com/2218-273X/12/1/30

Internet

https://www.mdpi.com/2218-273X/12/1/30

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