Combined RhoA morpholino and ChABC treatment protects identified lamprey neurons from retrograde apoptosis after spinal cord injury

Combined RhoA morpholino and ChABC treatment protects identified lamprey neurons from retrograde apoptosis after spinal cord injury

Previously, we reported that RhoA knockdown by morpholino antisense oligonucleotides (MOs), and enzymatic digestion of chondroitin sulfate proteoglycans (CSPGs) at the site of injury with chondroitinase ABC (ChABC), each can reduce retrograde neuronal apoptosis after spinal cord transection in the l...

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Bibliographic Details
Main Authors: Jianli Hu, Guixin Zhang, William Rodemer, Li-Qing Jin, Michael E. Selzer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neuronal apoptosis
axon regeneration
caspases
ChABC
RhoA
Akt
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1292012/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1292012/full

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