Combined RhoA morpholino and ChABC treatment protects identified lamprey neurons from retrograde apoptosis after spinal cord injury

Combined RhoA morpholino and ChABC treatment protects identified lamprey neurons from retrograde apoptosis after spinal cord injury

Previously, we reported that RhoA knockdown by morpholino antisense oligonucleotides (MOs), and enzymatic digestion of chondroitin sulfate proteoglycans (CSPGs) at the site of injury with chondroitinase ABC (ChABC), each can reduce retrograde neuronal apoptosis after spinal cord transection in the l...

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Bibliografski detalji
Glavni autori: Jianli Hu, Guixin Zhang, William Rodemer, Li-Qing Jin, Michael E. Selzer
Format: Članak
Jezik:English
Izdano: Frontiers Media S.A. 2023-12-01
Serija:Frontiers in Cellular Neuroscience
Teme:
neuronal apoptosis
axon regeneration
caspases
ChABC
RhoA
Akt
Online pristup:https://www.frontiersin.org/articles/10.3389/fncel.2023.1292012/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1292012/full

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