Metabolic Reprogramming of Mouse Bone Marrow Derived Macrophages Following Erythrophagocytosis

Metabolic Reprogramming of Mouse Bone Marrow Derived Macrophages Following Erythrophagocytosis

Reticuloendothelial macrophages engulf ∼0.2 trillion senescent erythrocytes daily in a process called erythrophagocytosis (EP). This critical mechanism preserves systemic heme-iron homeostasis by regulating red blood cell (RBC) catabolism and iron recycling. Although extensive work has demonstrated...

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Bibliographic Details
Main Authors: Alexis Catala, Lyla A. Youssef, Julie A. Reisz, Monika Dzieciatkowska, Nicholas E. Powers, Carlo Marchetti, Matthew Karafin, James C. Zimring, Krystalyn E. Hudson, Kirk C. Hansen, Steven L. Spitalnik, Angelo D’Alessandro
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
macrophage metabolism
omics technologies
blood
OXPHOS
mitochondrial dysregulation
pentose phosphate pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00396/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00396/full

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