Zoledronic acid inhibits the growth of leukemic MLL-AF9 transformed hematopoietic cells

Zoledronic acid inhibits the growth of leukemic MLL-AF9 transformed hematopoietic cells

A leukemic in vitro model produced by transducing Cord Blood derived-hematopoietic CD34+ cells with the MLL-AF9 translocation resulting in the oncogenic fusion protein, is used to assess for sensitivity to Zoledronic acid. These cells are practically immortalized and are of myeloid origin. Prolifera...

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Bibliographic Details
Main Authors: Emanuela Chiarella, Bruna Codispoti, Annamaria Aloisio, Emanuela G. Cosentino, Stefania Scicchitano, Ylenia Montalcini, Daniela Lico, Giovanni Morrone, Maria Mesuraca, Heather M. Bond
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Heliyon
Subjects:
Biological sciences
Cell biology
Biochemistry
Molecular biology
Cancer research
Acute myeloid leukemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020308641

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http://www.sciencedirect.com/science/article/pii/S2405844020308641

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