Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS.

Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS.

The whooping cough agent Bordetella pertussis coordinately regulates the expression of its virulence factors with the two-component system BvgAS. In laboratory conditions, specific chemical modulators are used to trigger phenotypic modulation of B. pertussis from its default virulent Bvg+ phase to a...

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Bibliographic Details
Main Authors: Elodie Lesne, Loic Coutte, Luis Solans, Stephanie Slupek, Anne-Sophie Debrie, Véronique Dhennin, Philippe Froguel, David Hot, Camille Locht, Rudy Antoine, Françoise Jacob-Dubuisson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6181320?pdf=render

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http://europepmc.org/articles/PMC6181320?pdf=render

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