Is There a Place for Lewy Bodies before and beyond Alpha-Synuclein Accumulation? Provocative Issues in Need of Solid Explanations

Is There a Place for Lewy Bodies before and beyond Alpha-Synuclein Accumulation? Provocative Issues in Need of Solid Explanations

In the last two decades, alpha-synuclein (alpha-syn) assumed a prominent role as a major component and seeding structure of Lewy bodies (LBs). This concept is driving ongoing research on the pathophysiology of Parkinson’s disease (PD). In line with this, alpha-syn is considered to be the guilty prot...

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Bibliographic Details
Main Authors: Paola Lenzi, Gloria Lazzeri, Michela Ferrucci, Marco Scotto, Alessandro Frati, Stefano Puglisi-Allegra, Carla Letizia Busceti, Francesco Fornai
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:International Journal of Molecular Sciences
Subjects:
sequestosome (p62)
poly-ubiquitin
phagophore
endosome
multivesicular bodies
retromer
Online Access:https://www.mdpi.com/1422-0067/25/7/3929

Internet

https://www.mdpi.com/1422-0067/25/7/3929

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