Resveratrol reduces store-operated Ca2+ entry and enhances the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats model via targeting ORAI1–STIM1 complex

Resveratrol reduces store-operated Ca2+ entry and enhances the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats model via targeting ORAI1–STIM1 complex

Abstract Background Resveratrol was reported to trigger the apoptosis of fibroblast-like synoviocytes in adjuvant arthritis rats but the subcellular mechanism remains unclear. Since ER stress, mitochondrial dysfunction and oxidative stress were involved in the effects of resveratrol with imbalance o...

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Bibliographic Details
Main Authors: Jinsen Lu, Jiazhao Yang, Yongshun Zheng, Shiyuan Fang, Xiaoyu Chen
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Biological Research
Subjects:
Resveratrol
Apoptosis
Store-operated calcium entry
STIM1
ORAI1
Online Access:http://link.springer.com/article/10.1186/s40659-019-0250-7

Internet

http://link.springer.com/article/10.1186/s40659-019-0250-7

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