Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

Idiopathic pulmonary fibrosis is associated with myofibroblast activation in the lungs and metabolic alterations. Here, the authors show that the antidiabetic drug metformin has antifibrotic effects in human-derived samples and mouse models, by modulating a number of metabolic pathways to induce lip...

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Bibliographic Details
Main Authors: Vahid Kheirollahi, Roxana M. Wasnick, Valentina Biasin, Ana Ivonne Vazquez-Armendariz, Xuran Chu, Alena Moiseenko, Astrid Weiss, Jochen Wilhelm, Jin-San Zhang, Grazyna Kwapiszewska, Susanne Herold, Ralph T. Schermuly, Bernard Mari, Xiaokun Li, Werner Seeger, Andreas Günther, Saverio Bellusci, Elie El Agha
Format: Article
Language:English
Published: Nature Portfolio 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10839-0

Internet

https://doi.org/10.1038/s41467-019-10839-0

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