Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
Idiopathic pulmonary fibrosis is associated with myofibroblast activation in the lungs and metabolic alterations. Here, the authors show that the antidiabetic drug metformin has antifibrotic effects in human-derived samples and mouse models, by modulating a number of metabolic pathways to induce lip...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10839-0 |
| _version_ | 1818342558525292544 |
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| author | Vahid Kheirollahi Roxana M. Wasnick Valentina Biasin Ana Ivonne Vazquez-Armendariz Xuran Chu Alena Moiseenko Astrid Weiss Jochen Wilhelm Jin-San Zhang Grazyna Kwapiszewska Susanne Herold Ralph T. Schermuly Bernard Mari Xiaokun Li Werner Seeger Andreas Günther Saverio Bellusci Elie El Agha |
| author_facet | Vahid Kheirollahi Roxana M. Wasnick Valentina Biasin Ana Ivonne Vazquez-Armendariz Xuran Chu Alena Moiseenko Astrid Weiss Jochen Wilhelm Jin-San Zhang Grazyna Kwapiszewska Susanne Herold Ralph T. Schermuly Bernard Mari Xiaokun Li Werner Seeger Andreas Günther Saverio Bellusci Elie El Agha |
| author_sort | Vahid Kheirollahi |
| collection | DOAJ |
| description | Idiopathic pulmonary fibrosis is associated with myofibroblast activation in the lungs and metabolic alterations. Here, the authors show that the antidiabetic drug metformin has antifibrotic effects in human-derived samples and mouse models, by modulating a number of metabolic pathways to induce lipogenic transdifferentiation of myofibroblasts. |
| first_indexed | 2024-12-13T16:16:36Z |
| format | Article |
| id | doaj.art-8abd0f7510244108a605662c2e07b3a9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:16:36Z |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8abd0f7510244108a605662c2e07b3a92022-12-21T23:38:49ZengNature PortfolioNature Communications2041-17232019-07-0110111610.1038/s41467-019-10839-0Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosisVahid Kheirollahi0Roxana M. Wasnick1Valentina Biasin2Ana Ivonne Vazquez-Armendariz3Xuran Chu4Alena Moiseenko5Astrid Weiss6Jochen Wilhelm7Jin-San Zhang8Grazyna Kwapiszewska9Susanne Herold10Ralph T. Schermuly11Bernard Mari12Xiaokun Li13Werner Seeger14Andreas Günther15Saverio Bellusci16Elie El Agha17Key Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical UniversityCardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University GiessenLudwig Boltzmann Institute for Lung Vascular Research, Otto Loewi Research Center, Medical University GrazCardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University GiessenCardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University GiessenCardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University GiessenCardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University GiessenCardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University GiessenInternational Collaborative Center on Growth Factor Research and School of Pharmaceutical Sciences, Wenzhou Medical UniversityLudwig Boltzmann Institute for Lung Vascular Research, Otto Loewi Research Center, Medical University GrazCardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University GiessenCardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University GiessenInstitut de Pharmacologie Moleculaire et Cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS), UMR 7275International Collaborative Center on Growth Factor Research and School of Pharmaceutical Sciences, Wenzhou Medical UniversityCardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University GiessenCardio-Pulmonary Institute (CPI) and Department of Pulmonary and Critical Care Medicine and Infectious Diseases, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus-Liebig University GiessenKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical UniversityKey Laboratory of Interventional Pulmonology of Zhejiang Province, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical UniversityIdiopathic pulmonary fibrosis is associated with myofibroblast activation in the lungs and metabolic alterations. Here, the authors show that the antidiabetic drug metformin has antifibrotic effects in human-derived samples and mouse models, by modulating a number of metabolic pathways to induce lipogenic transdifferentiation of myofibroblasts.https://doi.org/10.1038/s41467-019-10839-0 |
| spellingShingle | Vahid Kheirollahi Roxana M. Wasnick Valentina Biasin Ana Ivonne Vazquez-Armendariz Xuran Chu Alena Moiseenko Astrid Weiss Jochen Wilhelm Jin-San Zhang Grazyna Kwapiszewska Susanne Herold Ralph T. Schermuly Bernard Mari Xiaokun Li Werner Seeger Andreas Günther Saverio Bellusci Elie El Agha Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis Nature Communications |
| title | Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis |
| title_full | Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis |
| title_fullStr | Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis |
| title_full_unstemmed | Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis |
| title_short | Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis |
| title_sort | metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis |
| url | https://doi.org/10.1038/s41467-019-10839-0 |
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