Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males

Sex differences in renal cell carcinoma: a single-cell analysis reveals exhausted CD8+ T-cells highly infiltrated in males

Abstract Background Although sex bias has been reported in the development and progression of renal cell carcinoma (RCC), the underlying mechanisms remain enigmatic. Here, we investigated the sex differences in the tumor microenvironment (TME) of RCC and explored a promising combination drug regimen...

Full description

Bibliographic Details
Main Authors: Kang Ning, Yulu Peng, Yue Jiang, Zhen Li, Xin Luo, Lede Lin, Minhua Deng, Yi Wu, Tingxuan Huang, Yixin Huang, Ye Xie, Xiaofeng Yang, Manhuai Zhang, Longbin Xiong, Xiangpeng Zou, Zhaohui Zhou, Fangjian Zhou, Pei Dong, Chunping Yu, Zhiling Zhang
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Biology of Sex Differences
Subjects:
Sex bias
Renal cell carcinoma
Single-cell transcriptomics
Immunotherapy
T-cell
Exhaustion
Online Access:https://doi.org/10.1186/s13293-023-00540-9

Internet

https://doi.org/10.1186/s13293-023-00540-9

Similar Items