Integration of cancer stemness and neoantigen load to predict responsiveness to anti-PD1/PDL1 therapy

Integration of cancer stemness and neoantigen load to predict responsiveness to anti-PD1/PDL1 therapy

Background: Anti-programmed cell death 1/programmed cell death ligand 1 (PD1/PDL1) therapy is an important part of comprehensive cancer therapy. However, many patients suffer from non-response to therapy. Tumor neoantigen burden (TNB) and cancer stemness play essential roles in the responsiveness to...

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Bibliographic Details
Main Authors: Kunpeng Luo, Shuqiang Liu, Xiuyun Shen, Jincheng Xu, Chunpeng Shi, Yuqiu Chao, Zhengchao Wen, Kejiao Zhang, Ru Wang, Bing Liu, Yanan Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
tumor neoantigen burden
stemness
immunotherapy
drug resistance
prognostic model
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.1003656/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.1003656/full

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