Heparan Sulfate and Enoxaparin Interact at the Interface of the Spike Protein of HCoV-229E but Not with HCoV-OC43

Heparan Sulfate and Enoxaparin Interact at the Interface of the Spike Protein of HCoV-229E but Not with HCoV-OC43

It is known that the spike protein of human coronaviruses can bind to a secondary receptor, or coreceptor, to facilitate the virus entry. While HCoV-229E uses human aminopeptidase N (hAPN) as a receptor, HCoV-OC43 binds to 9-<i>O</i>-acetyl-sialic acid (9-<i>O</i>-Ac-Sia), wh...

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Bibliographic Details
Main Authors: Virginia Fuochi, Giuseppe Floresta, Rosalia Emma, Vincenzo Patamia, Massimo Caruso, Chiara Zagni, Federica Ronchi, Celestino Ronchi, Filippo Drago, Antonio Rescifina, Pio Maria Furneri
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Viruses
Subjects:
heparan sulfate
enoxaparin
coronavirus
HCoV-229E
HCoV-OC43
APN
Online Access:https://www.mdpi.com/1999-4915/15/3/663

Internet

https://www.mdpi.com/1999-4915/15/3/663

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