Scaffold Searching of FDA and EMA-Approved Drugs Identifies Lead Candidates for Drug Repurposing in Alzheimer’s Disease

Scaffold Searching of FDA and EMA-Approved Drugs Identifies Lead Candidates for Drug Repurposing in Alzheimer’s Disease

Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have consumed a significant amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Administration (FDA), European Medicines Agency (EMA), or Worldwide for another indicatio...

Podrobná bibliografie
Hlavní autoři:	Sergey Shityakov, Ekaterina V. Skorb, Carola Y. Förster, Thomas Dandekar
Médium:	Článek
Jazyk:	English
Vydáno:	Frontiers Media S.A. 2021-10-01
Edice:	Frontiers in Chemistry
Témata:	scaffold search approved drugs drug repurposing alzheimer's disease chemical similarity molecular modeling
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fchem.2021.736509/full

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