Scaffold Searching of FDA and EMA-Approved Drugs Identifies Lead Candidates for Drug Repurposing in Alzheimer’s Disease

Scaffold Searching of FDA and EMA-Approved Drugs Identifies Lead Candidates for Drug Repurposing in Alzheimer’s Disease

Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have consumed a significant amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Administration (FDA), European Medicines Agency (EMA), or Worldwide for another indicatio...

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Detalhes bibliográficos
Main Authors: Sergey Shityakov, Ekaterina V. Skorb, Carola Y. Förster, Thomas Dandekar
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2021-10-01
Colecção:Frontiers in Chemistry
Assuntos:
scaffold search
approved drugs
drug repurposing
alzheimer's disease
chemical similarity
molecular modeling
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fchem.2021.736509/full

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