Scaffold Searching of FDA and EMA-Approved Drugs Identifies Lead Candidates for Drug Repurposing in Alzheimer’s Disease

Scaffold Searching of FDA and EMA-Approved Drugs Identifies Lead Candidates for Drug Repurposing in Alzheimer’s Disease

Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have consumed a significant amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Administration (FDA), European Medicines Agency (EMA), or Worldwide for another indicatio...

Полное описание

Библиографические подробности
Главные авторы:	Sergey Shityakov, Ekaterina V. Skorb, Carola Y. Förster, Thomas Dandekar
Формат:	Статья
Язык:	English
Опубликовано:	Frontiers Media S.A. 2021-10-01
Серии:	Frontiers in Chemistry
Предметы:	scaffold search approved drugs drug repurposing alzheimer's disease chemical similarity molecular modeling
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fchem.2021.736509/full

Схожие документы

In silico repurposing of FDA-approved drugs as multi-target inhibitors of glioblastoma
по: Ridwan Abiodun Salaam, и др.
Опубликовано: (2025-03-01)

A Transcriptomics-Based Bioinformatics Approach for Identification and In Vitro Screening of FDA-Approved Drugs for Repurposing against Dengue Virus-2
по: Madhura Punekar, и др.
Опубликовано: (2022-09-01)

Editorial: Adopting drug repurposing to overcome drug resistance in cancer
по: Eswar Shankar, и др.
Опубликовано: (2023-04-01)

Network-based drug repurposing for potential stroke therapy
по: Qihui Wu, и др.
Опубликовано: (2023-01-01)

Approved drugs successfully repurposed against Leishmania based on machine learning predictions
по: Rafeh Oualha, и др.
Опубликовано: (2024-09-01)

Repurposing FDA‐Approved Compounds for the Discovery of Glutaminyl Cyclase Inhibitors as Drugs Against Alzheimer's Disease
по: Dr. Chenshu Xu, и др.
Опубликовано: (2021-09-01)

Screening of an FDA-Approved Library for Novel Drugs against <i>Y. pestis</i>
по: David Gur, и др.
Опубликовано: (2021-01-01)

Trends in FDA drug approvals over last 2 decades: An observational study
по: Angelika Batta, и др.
Опубликовано: (2020-01-01)

Computational Drug Repurposing Based on a Recommendation System and Drug–Drug Functional Pathway Similarity
по: Mengting Shao, и др.
Опубликовано: (2022-02-01)

Potential COVID-19 papain-like protease PLpro inhibitors: repurposing FDA-approved drugs
по: Valentina L. Kouznetsova, и др.
Опубликовано: (2020-09-01)

Repurposable Drugs for Immunotherapy and Strategies to Find Candidate Drugs
по: Norihiro Sakai, и др.
Опубликовано: (2023-08-01)

Drugs, Devices, and the FDA: Part 1
по: Gail A. Van Norman, MD
Опубликовано: (2016-04-01)

Trends and Perspectives of Biological Drug Approvals by the FDA: A Review from 2015 to 2021
по: Alexander C. Martins, и др.
Опубликовано: (2022-09-01)

Towards Drug Repurposing in Cancer Cachexia: Potential Targets and Candidates
по: Joana M. O. Santos, и др.
Опубликовано: (2021-10-01)

An empirical analysis of overall survival in drug approvals by the US FDA (2006–2023)
по: Josh Elbaz, и др.
Опубликовано: (2024-04-01)

Repurposing FDA-approved drugs targeting FZD10 in nasopharyngeal carcinoma: insights from molecular dynamics simulations and experimental validation
по: Chawalit Ngernsombat, и др.
Опубликовано: (2024-12-01)

Computational and Experimental Drug Repurposing of FDA-Approved Compounds Targeting the Cannabinoid Receptor CB1
по: Emanuele Criscuolo, и др.
Опубликовано: (2023-12-01)

Repurposing of Drug Candidates for Treatment of Skin Cancer
по: Hernán Cortés, и др.
Опубликовано: (2021-01-01)

Pathways for non-manufacturers to drive generic drug repurposing for cancer in the U.S.
по: Devon Crittenden, и др.
Опубликовано: (2024-10-01)

Drugs approved by CDSCO, India in 2015
по: K Parushuram Naik1 , V Sai Lakshmi2 , J Jyothirmai3
Опубликовано: (2016-04-01)

Repurposing FDA-approved drugs against multiple proteins of SARS-CoV-2: An in silico study
по: Alfred Olaoluwa Akinlalu, и др.
Опубликовано: (2021-09-01)

A review of new drugs approved by the food and drug administration in 2022
по: Arjun Swaminathan, и др.
Опубликовано: (2023-10-01)

Drug repurposing to tackle parainfluenza 3 based on multi-similarities and network proximity analysis
по: Xinyue Chen, и др.
Опубликовано: (2024-10-01)

Repurposed Drugs in Gastric Cancer
по: Diana Araújo, и др.
Опубликовано: (2022-12-01)

An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy
по: Juliana T. W. Tong, и др.
Опубликовано: (2021-09-01)

Repurposing Loperamide as an Anti-Infection Drug for the Treatment of Intracellular Bacterial Pathogens
по: Hongtao Liu, и др.
Опубликовано: (2024-08-01)

Drug Repositioning for Effective Prostate Cancer Treatment
по: Beste Turanli, и др.
Опубликовано: (2018-05-01)

Asymmetric Synthesis of US-FDA Approved Drugs over Five Years (2016–2020): A Recapitulation of Chirality
по: Rekha Tamatam, и др.
Опубликовано: (2023-02-01)

Design and synthesis of fluorine aromatic scaffolds containing drugs approved by the US FDA from 2002 to 2022
по: Pengfei Xu, и др.
Опубликовано: (2024-01-01)

Pharmacokinetic Profile of a Drug Repurposing Candidate for the Treatment of Cutaneous Leishmaniasis (in Silico)
по: Arlindo Gonzaga Branco Junior, и др.
Опубликовано: (2024-08-01)

Molecular docking of monkeypox (mpox) virus proteinase with FDA approved lead molecules
по: M.Valan Arasu, и др.
Опубликовано: (2023-05-01)

Antiviral Activity of Approved Antibacterial, Antifungal, Antiprotozoal and Anthelmintic Drugs: Chances for Drug Repurposing for Antiviral Drug Discovery
по: Abdulaziz L, и др.
Опубликовано: (2022-03-01)

The Repurposing of FDA-Approved Drugs as FtsZ Inhibitors against <i>Mycobacterium tuberculosis</i>: An In Silico and In Vitro Study
по: Andrea Michel Tovar-Nieto, и др.
Опубликовано: (2024-07-01)

In Vitro Drug Repurposing: Focus on Vasodilators
по: Eduarda Ribeiro, и др.
Опубликовано: (2023-02-01)

A review of the clinical efficacy of FDA-approved antibody‒drug conjugates in human cancers
по: Kaifeng Liu, и др.
Опубликовано: (2024-03-01)

Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules
по: Maria João Gouveia, и др.
Опубликовано: (2018-02-01)

Editorial: Drug Repurposing
по: Pan Pantziarka, и др.
Опубликовано: (2019-07-01)

Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects
по: Matthieu Chartier, и др.
Опубликовано: (2017-04-01)

Prospects for repurposing CNS drugs for cancer treatment
по: Mohamed Abdelaleem, и др.
Опубликовано: (2019-04-01)

Melatonin as a Repurposed Drug for Melanoma Treatment
по: Rachana Pathipaka, и др.
Опубликовано: (2023-01-01)