Scaffold Searching of FDA and EMA-Approved Drugs Identifies Lead Candidates for Drug Repurposing in Alzheimer’s Disease

Scaffold Searching of FDA and EMA-Approved Drugs Identifies Lead Candidates for Drug Repurposing in Alzheimer’s Disease

Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have consumed a significant amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Administration (FDA), European Medicines Agency (EMA), or Worldwide for another indicatio...

書目詳細資料
Main Authors:	Sergey Shityakov, Ekaterina V. Skorb, Carola Y. Förster, Thomas Dandekar
格式:	Article
語言:	English
出版:	Frontiers Media S.A. 2021-10-01
叢編:	Frontiers in Chemistry
主題:	scaffold search approved drugs drug repurposing alzheimer's disease chemical similarity molecular modeling
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fchem.2021.736509/full

相似書籍

In silico repurposing of FDA-approved drugs as multi-target inhibitors of glioblastoma
由: Ridwan Abiodun Salaam, et al.
出版: (2025-03-01)

A Transcriptomics-Based Bioinformatics Approach for Identification and In Vitro Screening of FDA-Approved Drugs for Repurposing against Dengue Virus-2
由: Madhura Punekar, et al.
出版: (2022-09-01)

Editorial: Adopting drug repurposing to overcome drug resistance in cancer
由: Eswar Shankar, et al.
出版: (2023-04-01)

Network-based drug repurposing for potential stroke therapy
由: Qihui Wu, et al.
出版: (2023-01-01)

Approved drugs successfully repurposed against Leishmania based on machine learning predictions
由: Rafeh Oualha, et al.
出版: (2024-09-01)

Repurposing FDA‐Approved Compounds for the Discovery of Glutaminyl Cyclase Inhibitors as Drugs Against Alzheimer's Disease
由: Dr. Chenshu Xu, et al.
出版: (2021-09-01)

Screening of an FDA-Approved Library for Novel Drugs against <i>Y. pestis</i>
由: David Gur, et al.
出版: (2021-01-01)

Trends in FDA drug approvals over last 2 decades: An observational study
由: Angelika Batta, et al.
出版: (2020-01-01)

Computational Drug Repurposing Based on a Recommendation System and Drug–Drug Functional Pathway Similarity
由: Mengting Shao, et al.
出版: (2022-02-01)

Potential COVID-19 papain-like protease PLpro inhibitors: repurposing FDA-approved drugs
由: Valentina L. Kouznetsova, et al.
出版: (2020-09-01)

Repurposable Drugs for Immunotherapy and Strategies to Find Candidate Drugs
由: Norihiro Sakai, et al.
出版: (2023-08-01)

Drugs, Devices, and the FDA: Part 1
由: Gail A. Van Norman, MD
出版: (2016-04-01)

Trends and Perspectives of Biological Drug Approvals by the FDA: A Review from 2015 to 2021
由: Alexander C. Martins, et al.
出版: (2022-09-01)

Towards Drug Repurposing in Cancer Cachexia: Potential Targets and Candidates
由: Joana M. O. Santos, et al.
出版: (2021-10-01)

An empirical analysis of overall survival in drug approvals by the US FDA (2006–2023)
由: Josh Elbaz, et al.
出版: (2024-04-01)

Repurposing FDA-approved drugs targeting FZD10 in nasopharyngeal carcinoma: insights from molecular dynamics simulations and experimental validation
由: Chawalit Ngernsombat, et al.
出版: (2024-12-01)

Computational and Experimental Drug Repurposing of FDA-Approved Compounds Targeting the Cannabinoid Receptor CB1
由: Emanuele Criscuolo, et al.
出版: (2023-12-01)

Repurposing of Drug Candidates for Treatment of Skin Cancer
由: Hernán Cortés, et al.
出版: (2021-01-01)

Pathways for non-manufacturers to drive generic drug repurposing for cancer in the U.S.
由: Devon Crittenden, et al.
出版: (2024-10-01)

Drugs approved by CDSCO, India in 2015
由: K Parushuram Naik1 , V Sai Lakshmi2 , J Jyothirmai3
出版: (2016-04-01)

Repurposing FDA-approved drugs against multiple proteins of SARS-CoV-2: An in silico study
由: Alfred Olaoluwa Akinlalu, et al.
出版: (2021-09-01)

A review of new drugs approved by the food and drug administration in 2022
由: Arjun Swaminathan, et al.
出版: (2023-10-01)

Drug repurposing to tackle parainfluenza 3 based on multi-similarities and network proximity analysis
由: Xinyue Chen, et al.
出版: (2024-10-01)

Repurposed Drugs in Gastric Cancer
由: Diana Araújo, et al.
出版: (2022-12-01)

An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy
由: Juliana T. W. Tong, et al.
出版: (2021-09-01)

Repurposing Loperamide as an Anti-Infection Drug for the Treatment of Intracellular Bacterial Pathogens
由: Hongtao Liu, et al.
出版: (2024-08-01)

Drug Repositioning for Effective Prostate Cancer Treatment
由: Beste Turanli, et al.
出版: (2018-05-01)

Asymmetric Synthesis of US-FDA Approved Drugs over Five Years (2016–2020): A Recapitulation of Chirality
由: Rekha Tamatam, et al.
出版: (2023-02-01)

Design and synthesis of fluorine aromatic scaffolds containing drugs approved by the US FDA from 2002 to 2022
由: Pengfei Xu, et al.
出版: (2024-01-01)

Pharmacokinetic Profile of a Drug Repurposing Candidate for the Treatment of Cutaneous Leishmaniasis (in Silico)
由: Arlindo Gonzaga Branco Junior, et al.
出版: (2024-08-01)

Molecular docking of monkeypox (mpox) virus proteinase with FDA approved lead molecules
由: M.Valan Arasu, et al.
出版: (2023-05-01)

Antiviral Activity of Approved Antibacterial, Antifungal, Antiprotozoal and Anthelmintic Drugs: Chances for Drug Repurposing for Antiviral Drug Discovery
由: Abdulaziz L, et al.
出版: (2022-03-01)

The Repurposing of FDA-Approved Drugs as FtsZ Inhibitors against <i>Mycobacterium tuberculosis</i>: An In Silico and In Vitro Study
由: Andrea Michel Tovar-Nieto, et al.
出版: (2024-07-01)

In Vitro Drug Repurposing: Focus on Vasodilators
由: Eduarda Ribeiro, et al.
出版: (2023-02-01)

A review of the clinical efficacy of FDA-approved antibody‒drug conjugates in human cancers
由: Kaifeng Liu, et al.
出版: (2024-03-01)

Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules
由: Maria João Gouveia, et al.
出版: (2018-02-01)

Editorial: Drug Repurposing
由: Pan Pantziarka, et al.
出版: (2019-07-01)

Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects
由: Matthieu Chartier, et al.
出版: (2017-04-01)

Prospects for repurposing CNS drugs for cancer treatment
由: Mohamed Abdelaleem, et al.
出版: (2019-04-01)

Melatonin as a Repurposed Drug for Melanoma Treatment
由: Rachana Pathipaka, et al.
出版: (2023-01-01)