The role of cholesterol and mitochondrial bioenergetics in activation of the inflammasome in IBD

The role of cholesterol and mitochondrial bioenergetics in activation of the inflammasome in IBD

Inflammatory Bowel Disease (IBD) is characterized by a loss of intestinal barrier function caused by an aberrant interaction between the immune response and the gut microbiota. In IBD, imbalance in cholesterol homeostasis and mitochondrial bioenergetics have been identified as essential events for a...

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Bibliographic Details
Main Authors: Jessica Astorga, Naschla Gasaly, Karen Dubois-Camacho, Marjorie De la Fuente, Glauben Landskron, Klaas Nico Faber, Félix A. Urra, Marcela A. Hermoso
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
IBD - inflammatory bowel disease
intracellular cholesterol accumulation
mitochondrial dysfunction
inflammasome
NLRP3 inflammasome
diet phytochemicals
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1028953/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1028953/full

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