Temperature Dependence of the Complexation Mechanism of Celecoxib and Hydroxyl-β-cyclodextrin in Aqueous Solution

Temperature Dependence of the Complexation Mechanism of Celecoxib and Hydroxyl-β-cyclodextrin in Aqueous Solution

Hydroxypropyl-β-cyclodextrin (HP-β-CD) is commonly used as a complexation reagent to solubilize compounds with poor aqueous solubility to improve in vivo dosing. However, the degree of solubility enhancement was often limited by the formation of only a 1:1 complex and a low complexation constant (K)...

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Bibliographic Details
Main Authors: Po-Chiang Chiang, Yue Shi, Yong Cui
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Pharmaceutics
Subjects:
molecular dynamics simulation
transition state
hydroxypropyl-β-cyclodextrin
celecoxib
solubilization
complexation
Online Access:http://www.mdpi.com/1999-4923/6/3/467

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http://www.mdpi.com/1999-4923/6/3/467

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