Enhancement of acarbose production by genetic engineering and fed-batch fermentation strategy in Actinoplanes sp. SIPI12-34

Enhancement of acarbose production by genetic engineering and fed-batch fermentation strategy in Actinoplanes sp. SIPI12-34

Abstract Background Acarbose, as an alpha-glucosidase inhibitor, is widely used clinically to treat type II diabetes. In its industrial production, Actinoplanes sp. SE50/110 is used as the production strain. Lack of research on its regulatory mechanisms and unexplored gene targets are major obstacle...

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Bibliographic Details
Main Authors: Zhenxin Li, Songbai Yang, Zhengyu Zhang, Yuanjie Wu, Jiawei Tang, Luoju Wang, Shaoxin Chen
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Microbial Cell Factories
Subjects:
Acarbose
Actinoplanes sp.
Transcriptome analysis
Genetic engineering
Multiple strategies
Fed-batch fermentation
Online Access:https://doi.org/10.1186/s12934-022-01969-0

Internet

https://doi.org/10.1186/s12934-022-01969-0

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