Role of GABRD Gene Methylation in the Nucleus Accumbens in Heroin-Seeking Behavior in Rats

Role of GABRD Gene Methylation in the Nucleus Accumbens in Heroin-Seeking Behavior in Rats

Epigenetic modifications such as DNA methylation play important roles in regulating gene expression and may mediate neuroplasticity and lead to drug-induced aberrant behaviors. Although several brain regions and neurobiological mechanisms have been suggested to be involved in these processes, there...

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Bibliographic Details
Main Authors: Qingxiao Hong, Wenjin Xu, Zi Lin, Jing Liu, Weisheng Chen, Huaqiang Zhu, Miaojun Lai, Dingding Zhuang, Zemin Xu, Dan Fu, Wenhua Zhou, Huifen Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
heroin
nucleus accumbens
GABRD
methylation
reinstatement
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.612200/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.612200/full

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