Plasma exosomes from patients with active thyroid-associated orbitopathy induce inflammation and fibrosis in orbital fibroblasts

Plasma exosomes from patients with active thyroid-associated orbitopathy induce inflammation and fibrosis in orbital fibroblasts

Abstract Background The pathogenesis of thyroid-associated orbitopathy (TAO) remains incompletely understand. The interaction between immunocytes and orbital fibroblasts (OFs) play a critical role in orbital inflammatory and fibrosis. Accumulating reports indicate that a significant portion of plasm...

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Bibliographic Details
Main Authors: Li Wei, Qinying Huang, Yunhai Tu, Shihan Song, Xiaobo Zhang, Bo Yu, Yufen Liu, Ziwei Li, Qing Huang, Lili Chen, Bo Liu, Shenglan Xu, Tong Li, Xiyuan Liu, Xiaozhou Hu, Weijie Liu, Zai-Long Chi, Wencan Wu
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Journal of Translational Medicine
Subjects:
Thyroid-associated orbitopathy
Exosome
miRNA
Immune response
Fibrosis
Online Access:https://doi.org/10.1186/s12967-024-05263-y

Internet

https://doi.org/10.1186/s12967-024-05263-y

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