Evolution of Natural Product Scaffolds as Potential Proteasome Inhibitors in Developing Cancer Therapeutics

Evolution of Natural Product Scaffolds as Potential Proteasome Inhibitors in Developing Cancer Therapeutics

Homeostasis between protein synthesis and degradation is a critical biological function involving a lot of precise and intricate regulatory systems. The ubiquitin-proteasome pathway (UPP) is a large, multi-protease complex that degrades most intracellular proteins and accounts for about 80% of cellu...

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Bibliographic Details
Main Authors: Reyaz Hassan Mir, Prince Ahad Mir, Jasreen Uppal, Apporva Chawla, Mitesh Patel, Fevzi Bardakci, Mohd Adnan, Roohi Mohi-ud-din
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Metabolites
Subjects:
ubiquitin-proteasome pathway
proteasome inhibitor
cancer
natural compounds
drug discovery
protein degradation
Online Access:https://www.mdpi.com/2218-1989/13/4/509

Internet

https://www.mdpi.com/2218-1989/13/4/509

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