Tumor Necrosis Factor-α Induces a Preeclamptic-like Phenotype in Placental Villi via Sphingosine Kinase 1 Activation

Tumor Necrosis Factor-α Induces a Preeclamptic-like Phenotype in Placental Villi via Sphingosine Kinase 1 Activation

Preeclampsia (PE) involves inadequate placental function. This can occur due to elevated pro-inflammatory tumor necrosis factor-α (TNF-α). In other tissues, TNF-α signals via sphingosine kinase 1 (SphK1). SphK1 hinders syncytial formation. Whether this occurs downstream of TNF-α signaling is unclear...

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Bibliographic Details
Main Authors: Yuliya Fakhr, Saloni Koshti, Yasaman Bahojb Habibyan, Kirsten Webster, Denise G. Hemmings
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
sphingolipids
inflammatory
sphingosine 1-phosphate
syncytium
Online Access:https://www.mdpi.com/1422-0067/23/7/3750

Internet

https://www.mdpi.com/1422-0067/23/7/3750

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