Apelin Promotes Endothelial Progenitor Cell Angiogenesis in Rheumatoid Arthritis Disease via the miR-525-5p/Angiopoietin-1 Pathway

Apelin Promotes Endothelial Progenitor Cell Angiogenesis in Rheumatoid Arthritis Disease via the miR-525-5p/Angiopoietin-1 Pathway

Angiogenesis is a critical process in the formation of new capillaries and a key participant in rheumatoid arthritis (RA) pathogenesis. The adipokine apelin (APLN) plays critical roles in several cellular functions, including angiogenesis. We report that APLN treatment of RA synovial fibroblasts (RA...

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Bibliographic Details
Main Authors: Ting-Kuo Chang, You-Han Zhong, Shan-Chi Liu, Chien-Chung Huang, Chun-Hao Tsai, Hsiang-Ping Lee, Shih-Wei Wang, Chin-Jung Hsu, Chih-Hsin Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
apelin
angiopoietin-1
endothelial progenitor cells (EPC)
rheumatoid arthritis
miR-525-5p
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.737990/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.737990/full

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