Renal ROCK Activation and Its Pharmacological Inhibition in Patients With Diabetes

Renal ROCK Activation and Its Pharmacological Inhibition in Patients With Diabetes

Rho-associated coiled-coil-containing protein kinase (ROCK) is a serine/threonine kinase with essential roles in cytoskeletal functions. Substantial evidence implicates ROCK as a critical regulator in the inception and progression of diabetic nephropathy through a mechanism involving mesangial fibro...

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Bibliographic Details
Main Authors: Keiichiro Matoba, Kensuke Sekiguchi, Yosuke Nagai, Yusuke Takeda, Hiroshi Takahashi, Tamotsu Yokota, Kazunori Utsunomiya, Rimei Nishimura
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
Rho-kinase (ROCK)
diabetic nephropathy
chronic kidney disease
diabetes
cell signaling
fasudil
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.738121/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.738121/full

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