PTEN and Other PtdIns(3,4,5)P<sub>3</sub> Lipid Phosphatases in Breast Cancer

PTEN and Other PtdIns(3,4,5)P<sub>3</sub> Lipid Phosphatases in Breast Cancer

The phosphoinositide 3-kinase (PI3K)/AKT signalling pathway is hyperactivated in ~70% of breast cancers. Class I PI3K generates PtdIns(3,4,5)P<sub>3</sub> at the plasma membrane in response to growth factor stimulation, leading to AKT activation to drive cell proliferation, survival and...

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Bibliographic Details
Main Authors: Mariah P. Csolle, Lisa M. Ooms, Antonella Papa, Christina A. Mitchell
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
phosphoinositide 3-kinase (PI3K)
AKT
inositol polyphosphate phosphatases
phosphatase tensin homolog deleted on chromosome 10 (PTEN)
proline rich inositol polyphosphate 5-phosphatase (PIPP)
Src homology 2-containing inositol phosphatase 2 (SHIP2)
Online Access:https://www.mdpi.com/1422-0067/21/23/9189

Internet

https://www.mdpi.com/1422-0067/21/23/9189

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