Dominant-negative signal transducer and activator of transcription (STAT)3 variants in adult patients: A single center experience

Dominant-negative signal transducer and activator of transcription (STAT)3 variants in adult patients: A single center experience

BackgroundAutosomal dominant hyper-IgE syndrome (AD-HIES) caused by dominant negative (DN) variants in the signal transducer and activator of transcription 3 gene (STAT3) is characterized by recurrent Staphylococcal abscesses, severe eczema, chronic mucocutaneous candidiasis (CMC), and non-immunolog...

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Bibliographic Details
Main Authors: Oded Shamriz, Limor Rubin, Amos J. Simon, Atar Lev, Ortal Barel, Raz Somech, Maya Korem, Sigal Matza Porges, Tal Freund, David Hagin, Ben Zion Garty, Amit Nahum, Vered Molho Pessach, Yuval Tal
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
stat3
hyper IgE syndrome
adults
inborn errors of imunity
dupilumab
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1044933/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1044933/full

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