DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II

DNA damage-induced transcription stress triggers the genome-wide degradation of promoter-bound Pol II

DNA damage inhibits elongating RNA polymerase II, but also initiates genome-wide transcriptional responses. Here the authors reveal that particularly promoter-bound Pol II is degraded upon DNA damage in a GSK3 signaling-mediated response.

Bibliographic Details
Main Authors: Barbara Steurer, Roel C. Janssens, Marit E. Geijer, Fernando Aprile-Garcia, Bart Geverts, Arjan F. Theil, Barbara Hummel, Martin E. van Royen, Bastiaan Evers, René Bernards, Adriaan B. Houtsmuller, Ritwick Sawarkar, Jurgen Marteijn
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31329-w

Internet

https://doi.org/10.1038/s41467-022-31329-w

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