Defining the impact of flavivirus envelope protein glycosylation site mutations on sensitivity to broadly neutralizing antibodies

Defining the impact of flavivirus envelope protein glycosylation site mutations on sensitivity to broadly neutralizing antibodies

ABSTRACT Antibodies targeting an envelope dimer epitope (EDE) cross-neutralize Zika virus (ZIKV) and dengue virus (DENV) and have thus inspired an epitope-focused vaccine design. There are two EDE antibody subclasses (EDE1, EDE2) distinguished by their dependence on viral envelope protein N-linked g...

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Bibliographic Details
Main Authors: Maya Contreras, Jackson B. Stuart, Lisa M. Levoir, Laura Belmont, Leslie Goo
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
flavivirus
broadly neutralizing antibodies
envelope glycosylation
Online Access:https://journals.asm.org/doi/10.1128/mbio.03048-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03048-23

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