A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution

A universal GlycoDesign for lysosomal replacement enzymes to improve circulation time and biodistribution

Currently available enzyme replacement therapies for lysosomal storage diseases are limited in their effectiveness due in part to short circulation times and suboptimal biodistribution of the therapeutic enzymes. We previously engineered Chinese hamster ovary (CHO) cells to produce α-galactosidase A...

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Bibliographic Details
Main Authors: Yen-Hsi Chen, Weihua Tian, Makiko Yasuda, Zilu Ye, Ming Song, Ulla Mandel, Claus Kristensen, Lorenzo Povolo, André R. A. Marques, Tomislav Čaval, Albert J. R. Heck, Julio Lopes Sampaio, Ludger Johannes, Takahiro Tsukimura, Robert Desnick, Sergey Y. Vakhrushev, Zhang Yang, Henrik Clausen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
glycoengineering
enzyme replacement therapy
lysosomal storage disease
glycoprotein therapeutics
bioengineering
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1128371/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2023.1128371/full

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