Deletion of PDK1 causes cardiac sodium current reduction in mice.

Deletion of PDK1 causes cardiac sodium current reduction in mice.

The AGC protein kinase family regulates multiple cellular functions. 3-phosphoinositide-dependent protein kinase-1 (PDK1) is involved in the pathogenesis of arrhythmia, and its downstream factor, Forkhead box O1 (Foxo1), negatively regulates the expression of the cardiac sodium channel, Nav1.5. Mice...

Full description

Bibliographic Details
Main Authors: Zhonglin Han, Yu Jiang, Yuqing Yang, Xuehan Li, Zhongzhou Yang, Kejiang Cao, Dao W Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4363661?pdf=render

Internet

http://europepmc.org/articles/PMC4363661?pdf=render

Similar Items