Epigalloccatechin-3-gallate Inhibits Ocular Neovascularization and Vascular Permeability in Human Retinal Pigment Epithelial and Human Retinal Microvascular Endothelial Cells via Suppression of MMP-9 and VEGF Activation

Epigalloccatechin-3-gallate Inhibits Ocular Neovascularization and Vascular Permeability in Human Retinal Pigment Epithelial and Human Retinal Microvascular Endothelial Cells via Suppression of MMP-9 and VEGF Activation

Epigalloccatechin-3-gallate (EGCG) is the main polyphenol component of green tea (leaves of Camellia sinensis). EGCG is known for its antioxidant, anti-inflammatory, antiviral, and anti-carcinogenic properties. Here, we identify EGCG as a new inhibitor of ocular angiogenesis and its vascular permeab...

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Bibliographic Details
Main Authors: Hak Sung Lee, Jae-Hyun Jun, Eun-Ha Jung, Bon Am Koo, Yeong Shik Kim
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:Molecules
Subjects:
EGCG
ARPE-19
HRMEC
ocular neovascularization
vascular permeability
MMP-9
VEGF
Online Access:http://www.mdpi.com/1420-3049/19/8/12150

Internet

http://www.mdpi.com/1420-3049/19/8/12150

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