MG53 Inhibits Necroptosis Through Ubiquitination-Dependent RIPK1 Degradation for Cardiac Protection Following Ischemia/Reperfusion Injury

MG53 Inhibits Necroptosis Through Ubiquitination-Dependent RIPK1 Degradation for Cardiac Protection Following Ischemia/Reperfusion Injury

RationaleWhile reactive oxygen species (ROS) has been recognized as one of the main causes of cardiac injury following myocardial infarction, the clinical application of antioxidants has shown limited effects on protecting hearts against ischemia–reperfusion (I/R) injury. Thus, the precise role of R...

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Bibliographic Details
Main Authors: Qiang Wang, Ki Ho Park, Bingchuan Geng, Peng Chen, Chunlin Yang, Qiwei Jiang, Frank Yi, Tao Tan, Xinyu Zhou, Zehua Bian, Jianjie Ma, Hua Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
redox
MG53
RIPK1
necroptosis
I/R injury
ubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.868632/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.868632/full

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