A Novel Class of Potent Anti-Tyrosinase Compounds with Antioxidant Activity, 2-(Substituted phenyl)-5-(trifluoromethyl)benzo[<i>d</i>]thiazoles: In Vitro and In Silico Insights

A Novel Class of Potent Anti-Tyrosinase Compounds with Antioxidant Activity, 2-(Substituted phenyl)-5-(trifluoromethyl)benzo[<i>d</i>]thiazoles: In Vitro and In Silico Insights

Sixteen compounds bearing a benzothiazole moiety were synthesized as potential tyrosinase inhibitors and evaluated for mushroom tyrosinase inhibitory activity. The compound 4-(5-(trifluoromethyl)benzo[<i>d</i>]thiazol-2-yl)benzene-1,3-diol (compound <b>1b</b>) exhibited the h...

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Bibliographic Details
Main Authors: YeJi Hwang, Jieun Lee, Hee Jin Jung, Sultan Ullah, Jeongin Ko, Yeongmu Jeong, Yu Jung Park, Min Kyung Kang, Hwayoung Yun, Min-Soo Kim, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antioxidants
Subjects:
anti-tyrosinase
radical scavenging activity
anti-melanogenesis
tyrosinase glycosylation
5-(trifluoromethyl)benzothiazole
B16F10 cells
Online Access:https://www.mdpi.com/2076-3921/11/7/1375

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https://www.mdpi.com/2076-3921/11/7/1375

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