High-frequency repetitive transcranial magnetic stimulation (rTMS) protects against ischemic stroke by inhibiting M1 microglia polarization through let-7b-5p/HMGA2/NF-κB signaling pathway

High-frequency repetitive transcranial magnetic stimulation (rTMS) protects against ischemic stroke by inhibiting M1 microglia polarization through let-7b-5p/HMGA2/NF-κB signaling pathway

Abstract Background Microglia assume opposite phenotypes in response to ischemic brain injury, exerting neurotoxic and neuroprotective effects under different ischemic stages. Modulating M1/M2 polarization is a potential therapy for treating ischemic stroke. Repetitive transcranial magnetic stimulat...

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Bibliographic Details
Main Authors: Ye Hong, Jinfeng Lyu, Lin Zhu, Xixi Wang, Mengna Peng, Xiangliang Chen, Qiwen Deng, Jie Gao, Zhenhua Yuan, Di Wang, Gelin Xu, Mengyi Xu
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Neuroscience
Subjects:
Ischemic stroke
Microglia polarization
rTMS
Let-7b-5p
HMGA2
NF-κB
Online Access:https://doi.org/10.1186/s12868-022-00735-7

Internet

https://doi.org/10.1186/s12868-022-00735-7

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